Scope and Limitations of Exploiting the Ability of the Chemosensitizer NV716 to Enhance the Activity of Tetracycline Derivatives against Pseudomonas aeruginosa
The spread of antibiotic resistance is an urgent threat to global health that requires new therapeutic approaches.Treatments for pathogenic Gram-negative bacteria are particularly challenging to identify due to the robust OM permeability barrier in these organisms.One strategy is to use antibiotic adjuvants, a class of drugs that have no significan